2,1,3-Benzothiadiazole-4-carbaldehyde → (S)-N-(benzo[c][1,2,5]thiadiazol-4-ylmethyl)-1,1-diethoxypropan-2-amine

HRID 2274643

반응식

HRID 2274643 반응식
[CH2:1]([O:3][CH:4]([O:8][CH2:9][CH3:10])[C@@H:5]([NH2:7])[CH3:6])[CH3:2].[N:11]1[S:12][N:13]=[C:14]2[C:19]([CH:20]=O)=[CH:18][CH:17]=[CH:16][C:15]=12>>[N:11]1[S:12][N:13]=[C:14]2[C:19]([CH2:20][NH:7][C@@H:5]([CH3:6])[CH:4]([O:8][CH2:9][CH3:10])[O:3][CH2:1][CH3:2])=[CH:18][CH:17]=[CH:16][C:15]=12

참가 물질

3

반응물 2

HCID 27762832,1,3-Benzothiadiazole-4-carbaldehydeHCID 12398111(2S)-1,1-Diethoxy-2-propanamine

생성물 1

HCID 67088326(S)-N-(benzo[c][1,2,5]thiadiazol-4-ylmethyl)-1,1-diethoxypropan-2-amine수율 95%

실험 절차

According to the procedure described in the synthesis method of Compound IX-5, (S)-1,1-diethoxypropan-2-amine (Compound XVIII-1) (883 mg, 6.0 mmol) was reacted with benzo[c][1,2,5]thiadiazole-4-carbaldehyde (837 mg, 5.1 mmol) to obtain the title compound (1.41 g, 95%).

출처 및 근거

ORD 기록
ord-e3d678c26ebd43bbbc95b8ff078d8552
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09126981B2

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