Ammonia → 6-Chloro-2-(methylthio)-5-nitropyrimidin-4-amine

HRID 2274988

반응식

HRID 2274988 반응식
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[C:6](Cl)[N:5]=[C:4]([S:12][CH3:13])[N:3]=1.CC[N:16](CC)CC.N>C1COCC1>[NH2:16][C:6]1[C:7]([N+:8]([O-:10])=[O:9])=[C:2]([Cl:1])[N:3]=[C:4]([S:12][CH3:13])[N:5]=1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 8471TriethylamineHCID 113454584,6-Dichloro-2-(methylthio)-5-nitropyrimidine

생성물 1

HCID 148930356-Chloro-2-(methylthio)-5-nitropyrimidin-4-amine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

To a solution of 4,6-dichloro-2-(methylthio)-5-nitropyrimidine (327 mg, 1.36 mmol) in THF (5.4 mL) at −10° C. was added Et3N (474 μL, 3.40 mmol) followed by a solution of NH3 (2.0 M in MeOH, 750 μL, 1.5 mmol). The mixture was stirred while warming to 0° C. for 1.5 h (LC/MS indicated consumption of starting materials.). The reaction mixture was taken forward without work-up.

후처리

  1. custom(LC/MS indicated consumption of starting materials.)

출처 및 근거

ORD 기록
ord-602123cb0f6744a9b132820ab0cb8299
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09127006B2

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