Potassium Hydroxide → 2-(6-Methoxypyridin-2-yl)-2-methylpropanoic acid

HRID 2275272노트

반응식

HRID 2275272 반응식
C([O:3][C:4](=[O:16])[C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[N:9]=1)([CH3:7])[CH3:6])C.[OH-].[K+]>CO>[CH3:15][O:14][C:10]1[N:9]=[C:8]([C:5]([CH3:7])([CH3:6])[C:4]([OH:16])=[O:3])[CH:13]=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 668349252-(6-Methoxy-pyridin-2-yl)-2-methyl-propionic acid ethyl ester

생성물 1

HCID 668349942-(6-Methoxypyridin-2-yl)-2-methylpropanoic acid수율 76.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-(6-Methoxy-pyridin-2-yl)-2-methyl-propionic acid ethyl ester (5.33 g) was dissolved in methanol (200 ml), added with 5 N aqueous solution of potassium hydroxide (25 ml), and then stirred under reflux. The reaction mixture was concentrated and neutralized with 2 N hydrochloric acid. The precipitated matters were collected by filtration and dried to obtain the title compound (3.55 g).

후처리

  1. temperatureunder reflux
  2. concentrationThe reaction mixture was concentrated
  3. filtrationThe precipitated matters were collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-2446ba39fc024c3e9644202174e3d690
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09126931B2

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