Benzofuran → 2-[1-(2-Bromo-4-methoxyphenyl)-1-methylethyl]benzofuran
반응식
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10](O)([CH3:12])[CH3:11].[CH:14]1[CH:19]=[C:18]2[CH:20]=[CH:21][O:22][C:17]2=[CH:16][CH:15]=1>O>[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10]([C:21]1[O:22][C:17]2[CH:16]=[CH:15][CH:14]=[CH:19][C:18]=2[CH:20]=1)([CH3:12])[CH3:11]참가 물질
4
반응 조건
- 온도
- 90 °C
실험 절차
Mixture comprising 2-(2-bromo-4-methoxyphenyl)-propan-2-ol (100 mg), 2,3-benzofuran (0.19 ml) and polyphosphoric acid (1 g) was stirred and heated at 90° C. for 30 min. The reaction mixture was added with water and extracted with DCM. The residues obtained after concentration under reduced pressure were purified by silica gel column (DCM/hexane) to obtain the title compound (143 mg, 51%).