Oxalyl chloride → 2-[1-(2-Bromo-5-methoxy-phenyl)-cyclopropyl]-benzofuran

To the DCM solution (6 ml) of 1-(2-bromo-5-methoxy-phenyl)-cyclopropane carboxylic acid (0.3 g, 1.1 mmol), DMF (2 drops) and oxalyl chloride (0.23 ml, 2.5 mmol) were added at room temperature, and the mixture was stirred at room temperature for 2 hrs. The residues obtained from the reaction solution after concentration under reduced pressure were dissolved in toluene (6 ml), added with (2-hydroxybenzyl)triphenylphosphonium bromide (0.605 g, 1.32 mmol) and TEA (0.46 ml, 3.3 mmol), and the resulting mixture was stirred and heated at 100° C. overnight. The residues obtained after concentration under reduced pressure were purified by silica gel column (hexane:DCM) to obtain the title compound (0.309 g, 81%).

1. customThe residues obtained from the reaction solution
2. concentrationafter concentration under reduced pressure
3. dissolutionwere dissolved in toluene (6 ml)
4. stirringthe resulting mixture was stirred
5. temperatureheated at 100° C. overnight
6. customThe residues obtained
7. concentrationafter concentration under reduced pressure
8. customwere purified by silica gel column (hexane:DCM)

ORD 기록

ord-dea6a87af2e24481bcd47c382a250b06

출처 데이터셋

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US09126931B2