alpha-Methyltryptophan → HCID 68849237, 화합물

HRID 2275397

반응식

HRID 2275397 반응식
[CH3:1][C:2]([C:14](O)=[O:15])([CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1)[NH2:3]>C1COCC1>[NH2:3][C:2]([CH3:1])([CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1)[CH2:14][OH:15]

참가 물질

3

반응물 1

HCID 95438alpha-Methyltryptophan

생성물 1

HCID 68849237HCID 68849237, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
65 °C

실험 절차

To a solution of alpha-methyl-DL-tryptophan (100 mg) in dry THF (10 ml) was added a borane-tetrahydrofuran complex (1.14 ml) dropwise. The reaction mixture was heated at 65° C. for 4.5 hours. The reaction mixture was quenched with ethanol (3 ml). The reaction mixture was concentrated and extracted with ethyl acetate and water. The organic layer was dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by preparative HPLC eluting with acetonitrile and water. The pure fractions were collected and freezedried.

후처리

  1. customThe reaction mixture was quenched with ethanol (3 ml)
  2. concentrationThe reaction mixture was concentrated
  3. extractionextracted with ethyl acetate and water
  4. dry with materialThe organic layer was dried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customThe residue was purified by preparative HPLC
  8. washeluting with acetonitrile and water
  9. customThe pure fractions were collected
  10. customfreezedried

출처 및 근거

ORD 기록
ord-0fb0c1dc1df1450daeb532bb4f95ee12
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09127007B2

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