참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | Ethyl chloroformate | HCID 10928 | — |
| 반응물 | 2-Amino-6-chlorobenzoic acid | HCID 75071 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 5-Chloroisatoic anhydride | HCID 78480 | 97% |
반응 단계
2-Amino-6-chlorobenzoic acid (30 g) was suspended in 1,4-dioxane (225 ml) and ethyl chloroformate (75 ml) was added. The mixture was heated at reflux for 1 hour, then cooled to 50° C., and acetyl chloride (75 ml) was added. The mixture was stirred for 10 hours, after which the precipitated product was filtered off and washed with toluene. Drying in vacuum yields 5-chloroisatoic anhydride (33 g, 97% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07560557B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_07 |
|---|
| ORD ID | ord-95d444a5725d4f3d89bff7eb6a69388c |
|---|
| 출처 메모 | uspto-grants-2009_07 |
|---|
