Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Donepezil Hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Donepezil | HCID 3152 | — |
| 반응물 | Diisopropyl Ether | HCID 7914 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | Donepezil Hydrochloride | HCID 5741 | — |
반응 단계
Donepezil free base (4.0 gm) is dissolved in ethylene dichloride (20 ml) at 27° C., conc. hydrochloric acid (1.2 ml) is added to the solution and stirred for 2 hours at 25° C. to 30° C. Then diisopropyl ether (75 ml) is added and the precipitated solid is filtered off and dried to give 3.0 gm of donepezil hydrochloride form H1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07560560B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-526665e5b2a6411daa8886dec93bd9b1 |
| 출처 메모 | uspto-grants-2009_07 |