Methylamine → HCID 90136020, 화합물

HRID 2275799노트

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HRID 2275799 반응식
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH:12]([CH2:25][O:26][CH:27]([CH3:29])[CH3:28])[CH2:13][NH:14][C:15](=[O:24])[O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.CN>C(O)C>[NH2:3][CH:12]([CH2:25][O:26][CH:27]([CH3:29])[CH3:28])[CH2:13][NH:14][C:15](=[O:24])[O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 90136015HCID 90136015, 화합물

생성물 1

HCID 90136020HCID 90136020, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

2.3 g of rac-benzyl [2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-isopropoxypropyl]carbamate (5.6 mmol, 1 equivalent) were dissolved in 30 ml of ethanol, 7.3 ml of 40% strength aqueous methylamine solution (84.4 mmol, 15 equivalent) were added and the mixture was stirred at 60° C. overnight. The reaction mixture was concentrated and the residue was then chromatographed on silica gel (Biotage Isolera; mobile phase: dichloromethane/methanol gradient). This gave 730 mg (49% of theory) of the title compound.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was then chromatographed on silica gel (Biotage Isolera; mobile phase: dichloromethane/methanol gradient)

출처 및 근거

ORD 기록
ord-6ff07479a06141db929e6d6bde54de3d
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09126998B2

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