Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Nitroacetophenone → (2E)-1-(4-nitrophenyl)-3-pyridin-4-ylprop-2-en-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Nitroacetophenone | HCID 7487 | — |
| 반응물 | 4-Pyridinecarboxaldehyde | HCID 13389 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Water ethanol | HCID 19096565 | — |
| 생성물 | (2E)-1-(4-nitrophenyl)-3-pyridin-4-ylprop-2-en-1-one | HCID 6088197 | 25.3% |
반응 단계
A suspension of 4′-nitroacetophenone (5 g, 30.3 mmol) and 4-pyridinecarboxaldehyde (2.89 mL, 30.3 mmol) in water (45 mL) at room temperature was treated with 6% NaOH in H2O/ethanol (2:1)(0.606 mL), stirred overnight, and filtered. The filter cake was washed with water and small amount of ethanol then triturated with dichloromethane to provide 1.95 g (25%) of the desired product. MS(ESI(+)) m/e 255 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07560552B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-66be6540069849619d3c20efa2b68ca7 |
| 출처 메모 | uspto-grants-2009_07 |