Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
m-Tolylisothiocyanate → Thienopyrimidine deriv. 65
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | m-Tolylisothiocyanate | HCID 69304 | — |
| 반응물 | 5-(4-Aminophenyl)-6-methylthieno[2,3-d]pyrimidin-4-amine | HCID 6539968 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Thienopyrimidine deriv. 65 | HCID 6539974 | 80% |
반응 단계
A solution of Example 1E (60 mg, 0.23 mmol) and 3-methylphenyl isothiocyanate in DMF (2 mL) was stirred at room temperature, for 48 hours, quenched with water, and filtered. The filter cake was dried to provide the desired product (75 mg, 80%). MS(ESI(+)) m/e 406 (M+H)+; 1H NMR (300 MHz, DMSO-d6) δ 9.96 (s, 1H); 9.84 (s, 1H); 8.27 (s, 1H); 7.65 (d, J=8.4 Hz, 2H); 7.35 (d, J=8.4 Hz, 2H); 7.30-7.18 (m, 3H); 6.97 (d, J=6.9 Hz, 1H); 2.30 (s, 6H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07560552B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-e9e43410ddf145fcad3dadf6b8e5628a |
| 출처 메모 | uspto-grants-2009_07 |