Boron tribromide → 4-Hydroxy-trans-stilbene
반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6](/[CH:9]=[CH:10]/[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:5][CH:4]=1.B(Br)(Br)Br>C(Cl)Cl>[OH:2][C:3]1[CH:4]=[CH:5][C:6](/[CH:9]=[CH:10]/[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:7][CH:8]=1참가 물질
4
반응 조건
- 온도
- -5 °C
실험 절차
To 210 mg (1 mmol) of (E)-4-methoxystilbene (4b) in 7 mL of CH2Cl2 was added 1.28 mL of 1M BBr3 (1.3 mmol) in dichloromethane at −10° C. The mixture was stirred for 4 h at −5° C. and quenched by pouring into cold water. The product was extracted with CH2Cl2, dried over anhydrous MgSO4 and chromatographed using 1:10 CH3OH:CH2Cl2 to afford 85 mg (43%) of 4a. mp 184-185° C.
후처리
- customquenched
- additionby pouring into cold water
- extractionThe product was extracted with CH2Cl2
- dry with materialdried over anhydrous MgSO4
- customchromatographed
출처 및 근거
- ORD 기록
- ord-a3ebcee1b39f412393865af02bbcf999
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09132102B2
반응 노트
불러오는 중…