Chlorosuccinimide → 1-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone

HRID 2276315노트

반응식

HRID 2276315 반응식
[Cl:1]N1C(=O)CCC1=O.[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]>CN(C=O)C>[CH2:9]([N:13]1[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([Cl:1])[C:14]1=[O:20])[CH2:10][CH2:11][CH3:12]

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 594970761-butyl-4-hydroxy-1H-pyridine-2-one

생성물 1

HCID 594970741-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone수율 83%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

N-Chlorosuccinimide (1.6 g, 11.96 mmol) was added to a solution of intermediate D5 (2.0 g, 11.96 mmol) in DMF (30 ml). The reaction was stirred at room temperature overnight and then it was concentrated in vacuo. The crude product was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent) to yield intermediate D8 (2.0 g, 83%).

후처리

  1. concentrationit was concentrated in vacuo
  2. customThe crude product was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent)

출처 및 근거

ORD 기록
ord-35745f7d93154ed8bc95101e812b8531
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09132122B2

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