Methyl cyanoacetate → HCID 28473083, 화합물

HRID 2276416노트

반응식

HRID 2276416 반응식
[Cl:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4](Cl)=[N:5][OH:6].[CH3:12][O:13][C:14](=[O:18])[CH2:15][C:16]#[N:17].C[O-].[Na+]>CO>[CH3:12][O:13][C:14]([C:15]1[C:4]([C:3]2[CH:8]=[CH:9][CH:10]=[CH:11][C:2]=2[Cl:1])=[N:5][O:6][C:16]=1[NH2:17])=[O:18]

참가 물질

5

반응물 3

HCID 7747Methyl cyanoacetateHCID 38097332-Chloro-N-hydroxy-benzamidineHCID 10942334Sodium Methoxide

생성물 1

HCID 28473083HCID 28473083, 화합물수율 88.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In a similar manner as described in Preparation Example 17, by using methanol (160 mL), 2-chloro-N-hydroxybenzimidoylchloride (8.00 g, 42.10 mmol), methylcyanoacetate (5.22 g, 52.63 mmol) and sodium methoxide (4.55 g, 84.20 mmol), a white solid required compound (9.40 g, 37.21 mmol, 88%) was obtained.

후처리

  1. customIn a similar manner as described in Preparation Example 17

출처 및 근거

ORD 기록
ord-b64565e58b2041b2a13168aa9d8bb4ff
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09132126B2

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