Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(3-methoxyphenyl)piperazine → (3-(2-Fluorophenyl)-5-methylisoxazol-4-yl)(4-(3-methoxyphenyl)piperazine-1-yl)methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(3-methoxyphenyl)piperazine | HCID 81430 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 3-(2-Fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid | HCID 6484101 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (3-(2-Fluorophenyl)-5-methylisoxazol-4-yl)(4-(3-methoxyphenyl)piperazine-1-yl)methanone | HCID 66576941 | 86% |
반응 단계
In a similar manner as described in Example 1, by using dichloromethane (30 mL), 3-(2-fluorophenyl)-5-methylisoxazol-4-carboxylic acid (407 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol) and 1-(3-methoxyphenyl)piperazine (354 mg, 1.84 mmol), a white solid required compound (622 mg, 1.57 mmol, 86%) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09132126B2 |
| 출처 데이터셋 | uspto-grants-2015_09 |
| ORD ID | ord-6e20739303544a8cb9570726b6f1711c |
| 출처 메모 | uspto-grants-2015_09 |