2-Cyclopenten-1-one → (3R)-3-[4-(Benzyloxy)phenyl]cyclopentanone

HRID 2276840노트

반응식

HRID 2276840 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11](OB(O)O)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19]1(=[O:24])[CH2:23][CH2:22][CH:21]=[CH:20]1>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C@@H:21]2[CH2:22][CH2:23][C:19](=[O:24])[CH2:20]2)=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 135882-Cyclopenten-1-oneHCID 230941703-Benzyloxyphenylboric acid

생성물 1

HCID 67296394(3R)-3-[4-(Benzyloxy)phenyl]cyclopentanone수율 104.5%

실험 절차

3-Benzyloxyphenylboric acid (15.0 g, 66 mmol) and cyclopentenone (2.5 mL, 30 mmol) were used and treated in a similar manner to (Step 1) of (Example 3) to give the title compound (8.35 g).

후처리

  1. additiontreated in a similar manner to (Step 1) of (Example 3)

출처 및 근거

ORD 기록
ord-e2d8a3b6fd52418a805d9db1dbaa3789
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133140B2

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