5-Nitroindazole → HCID 178526490, 화합물

HRID 227698노트

반응식

HRID 227698 반응식
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[CH:7]2)([O-:3])=[O:2].[Br:13]Br>CO>[Br:13][C:7]1[C:6]2[C:10](=[CH:11][CH:12]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[NH:9][N:8]=1

참가 물질

4

반응물 2

HCID 215015-NitroindazoleHCID 24408Bromine

생성물 1

HCID 178526490HCID 178526490, 화합물수율 112.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a stirred suspension of 5-Nitro-1H-indazole (15.0 g, 92.0 mmol) in 400 ml methanol was added bromine (4.7 ml, 92.0 mmol) dropwise at room temperature. The mixture was stirred at room temperature overnight. The solvent was evaporated to dryness to afford the title compound, (25.0 g, 100%); MS (ES+) m/e 243 [M+H]+.

후처리

  1. customThe solvent was evaporated to dryness

출처 및 근거

ORD 기록
ord-48ea08ab914d4746978e2661d811f3fa
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560467B2

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