HCID 57517503, 화합물 → 4-(Cyclopropylmethoxy)-3-fluorobenzenamine

HRID 2277153노트

반응식

HRID 2277153 반응식
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][C:7]=2[F:15])[CH2:3][CH2:2]1>[C].[Pd].C1COCC1>[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][C:7]=2[F:15])[CH2:2][CH2:3]1

참가 물질

4

반응물 1

HCID 57517503HCID 57517503, 화합물

생성물 1

HCID 196272444-(Cyclopropylmethoxy)-3-fluorobenzenamine수율 99.8%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 1-(cyclopropylmethoxy)-2-fluoro-4-nitrobenzene (3.00 g), 10% palladium-carbon (containing water (50%), 3.00 g) and THF (30 mL) was stirred at room temperature for 1 hr under a hydrogen atmosphere. The catalyst was removed by filtration, and the obtained filtrate was concentrated under reduced pressure to give the title compound (2.57 g).

후처리

  1. customThe catalyst was removed by filtration
  2. concentrationthe obtained filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-83e46c465d924d5cb0690b86679b2380
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133129B2

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