Ethyl Acetate → 4-(cyclopropylmethoxy)-N-(4,6-dichloropyridin-3-yl)benzamide

HRID 2277178노트

반응식

HRID 2277178 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][C:3]=1[NH2:9].[CH:10]1([CH2:13][O:14][C:15]2[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=2)[CH2:12][CH2:11]1.C(OCC)(=O)C>N1C=CC=CC=1.C1COCC1>[CH:10]1([CH2:13][O:14][C:15]2[CH:16]=[CH:17][C:18]([C:19]([NH:9][C:3]3[CH:4]=[N:5][C:6]([Cl:8])=[CH:7][C:2]=3[Cl:1])=[O:20])=[CH:22][CH:23]=2)[CH2:12][CH2:11]1

참가 물질

6

반응물 3

HCID 8857Ethyl AcetateHCID 5957294,6-Dichloropyridin-3-amineHCID 867312344-(Cyclopropylmethoxy)benzoyl chloride

생성물 1

HCID 867312334-(cyclopropylmethoxy)-N-(4,6-dichloropyridin-3-yl)benzamide수율 36.3%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4,6-dichloropyridin-3-amine (2.00 g) in pyridine (30 mL) was added a solution of 4-(cyclopropylmethoxy)benzoyl chloride (3.88 g) in THF (5 mL), and the mixture was stirred at room temperature for 10 min. The reaction mixture was subjected to silica gel column chromatography (NH, ethyl acetate), and the solvent was evaporated, and the obtained solid was washed with diethyl ether/hexane to give the title compound (1.50 g).

후처리

  1. customthe solvent was evaporated
  2. washthe obtained solid was washed with diethyl ether/hexane

출처 및 근거

ORD 기록
ord-66fdf7dd845747758c5b14d7fc8c2717
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133129B2

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