Oxalyl chloride → 4-(Cyclopropylmethoxy)-3-fluorobenzoyl chloride
반응식
[CH:1]1([CH2:4][O:5][C:6]2[CH:14]=[CH:13][C:9]([C:10](O)=[O:11])=[CH:8][C:7]=2[F:15])[CH2:3][CH2:2]1.C(Cl)(=O)C([Cl:19])=O>C1COCC1.CN(C=O)C>[CH:1]1([CH2:4][O:5][C:6]2[CH:14]=[CH:13][C:9]([C:10]([Cl:19])=[O:11])=[CH:8][C:7]=2[F:15])[CH2:3][CH2:2]1참가 물질
5
실험 절차
To a solution of 4-(cyclopropylmethoxy)-3-fluorobenzoic acid (1.57 g) in THF (50 mL) were added oxalyl dichloride (0.982 mL) and DMF (2 drops), and the mixture was stirred at room temperature for 30 min. The solvent was evaporated under reduced pressure to give 4-(cyclopropylmethoxy)-3-fluorobenzoyl chloride. This compound was used for the next reaction without further purification.
후처리
- customThe solvent was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-5d20af099d34407f9ba706d37a4467ca
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09133129B2
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