Diketene → HCID 178468064, 화합물

HRID 227722노트

반응식

HRID 227722 반응식
[Br:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH2:11])[CH:9]=2)[NH:4][N:3]=1.[CH2:12]=[C:13]1[O:17][C:15](=[O:16])[CH2:14]1>CC#N>[Br:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][C:15](=[O:16])[CH2:14][C:13](=[O:17])[CH3:12])[CH:9]=2)[NH:4][N:3]=1

참가 물질

4

반응물 2

HCID 12661Diketene2회HCID 178507356HCID 178507356, 화합물

생성물 1

HCID 178468064HCID 178468064, 화합물수율 26%

시약·촉매·용매 1

HCID 6342Acetonitrile용매2회

반응 조건

온도
50 °C

실험 절차

The product of Step (b) (4.00 g, 18.86 mmol, 1 equiv) was suspended In CH3CN (20 mL). In a separate flask, diketene (1.45 mL, 18.89 mmol, 1 equiv) was dissolved in CH3CN (10 mL) The diketene solution was added to the initial suspension, and the mixture was heated to 50° C. for 18 hours. The reaction mixture was cooled and concentrated en vacuo. The resulting residue was purified by flash chromatography to afford 1.47 g (26%) of the product as a pink solid.

후처리

  1. temperatureThe reaction mixture was cooled
  2. concentrationconcentrated en vacuo
  3. customThe resulting residue was purified by flash chromatography

출처 및 근거

ORD 기록
ord-4174d3a74dc64a7c9ee1226d011a163d
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560467B2

반응 노트

불러오는 중…