(2,2-Difluorocyclopropyl)methanol → HCID 86731301, 화합물

HRID 2277230

반응식

HRID 2277230 반응식
C(O[C:9]1[C:14]([F:15])=[CH:13][C:12]([C:16]2[O:17][C:18]3[CH:23]=[C:22]([O:24][CH2:25][C@@H:26]([NH:28][C:29](=[O:31])[CH3:30])[CH3:27])[N:21]=[CH:20][C:19]=3[N:32]=2)=[C:11]([F:33])[CH:10]=1)C1C=CC=CC=1.[F:34][C:35]1([F:40])[CH2:37][CH:36]1[CH2:38][OH:39]>>[F:34][C:35]1([F:40])[CH2:37][CH:36]1[CH2:38][O:39][C:9]1[C:14]([F:15])=[CH:13][C:12]([C:16]2[O:17][C:18]3[CH:23]=[C:22]([O:24][CH2:25][C@@H:26]([NH:28][C:29](=[O:31])[CH3:30])[CH3:27])[N:21]=[CH:20][C:19]=3[N:32]=2)=[C:11]([F:33])[CH:10]=1

참가 물질

3

반응물 2

HCID 2761401(2,2-Difluorocyclopropyl)methanolHCID 86731302HCID 86731302, 화합물

생성물 1

HCID 86731301HCID 86731301, 화합물

실험 절차

Using N-((2S)-1-((2-(4-(benzyloxy)-2,5-difluorophenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide and (2,2-difluorocyclopropyl)methanol, and in the same manner as in Step A and Step B of Example 4, the title compound was obtained.

출처 및 근거

ORD 기록
ord-9469dbca968d458a814062308f406bfd
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133129B2

연결된 노트

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