6-Chloronicotinic acid → 6-((2,2-difluorocyclopropyl)methoxy)nicotinic Acid

HRID 2277244

반응식

HRID 2277244 반응식
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[F:11][C:12]1([F:17])[CH2:14][CH:13]1[CH2:15][OH:16]>>[F:11][C:12]1([F:17])[CH2:14][CH:13]1[CH2:15][O:16][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 792226-Chloronicotinic acidHCID 2761401(2,2-Difluorocyclopropyl)methanol

생성물 1

HCID 867313186-((2,2-difluorocyclopropyl)methoxy)nicotinic Acid

실험 절차

Using 6-chloronicotinic acid and 2,2-difluorocyclopropanemethanol, and in the same manner as in Step A of Example 40, the title compound was obtained.

출처 및 근거

ORD 기록
ord-46b035dab57640e7b6248572d3ecd9de
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133129B2

연결된 노트

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