Bromine → 5-(Benzyloxy)-3-bromopyridin-2-amine

HRID 2277252노트

반응식

HRID 2277252 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([NH2:15])=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:16]Br.C(=O)([O-])O.[Na+]>C(O)(=O)C>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([Br:16])[C:12]([NH2:15])=[N:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 223152765-(Benzyloxy)pyridin-2-amine

생성물 1

HCID 582090735-(Benzyloxy)-3-bromopyridin-2-amine

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 5-(benzyloxy)pyridin-2-amine (10.2 g) in acetic acid (50 mL) was added bromine (2.61 mL) at 0° C., and the mixture was stirred for 2 hr. To the reaction mixture was added saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The obtained organic layer was dried over anhydrous magnesium sulfate, the solvent was evaporated, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (8.50 g).

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe obtained organic layer was dried over anhydrous magnesium sulfate
  3. customthe solvent was evaporated
  4. customthe residue was purified by silica gel column chromatography (hexane/ethyl acetate)

출처 및 근거

ORD 기록
ord-aa492df8b50740169374dbc757993210
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133129B2

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