4-((2,2-Difluorocyclopropyl)methoxy)benzoic acid → HCID 178461782, 화합물

HRID 2277293노트

반응식

HRID 2277293 반응식
C([O:8][C:9]1[C:14]([N+:15]([O-])=O)=[CH:13][N:12]=[C:11]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH3:21])[N:10]=1)C1C=CC=CC=1.[F:30][C:31]1([F:45])[CH2:33][CH:32]1[CH2:34][O:35][C:36]1[CH:44]=[CH:43][C:39]([C:40](O)=[O:41])=[CH:38][CH:37]=1>>[F:30][C:31]1([F:45])[CH2:33][CH:32]1[CH2:34][O:35][C:36]1[CH:44]=[CH:43][C:39]([C:40]([NH:15][C:14]2[C:9]([OH:8])=[N:10][C:11]([O:18][CH2:19][C@@H:20]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH3:21])=[N:12][CH:13]=2)=[O:41])=[CH:38][CH:37]=1

참가 물질

3

반응물 2

HCID 690200884-((2,2-Difluorocyclopropyl)methoxy)benzoic acidHCID 86731375tert-butyl ((2S)-1-((4-(benzyloxy)-5-nitropyrimidin-2-yl)oxy)propan-2-yl)carbamate

생성물 1

HCID 178461782HCID 178461782, 화합물

실험 절차

Using tert-butyl ((2S)-1-((4-(benzyloxy)-5-nitropyrimidin-2-yl)oxy)propan-2-yl)carbamate and 4-((2,2-difluorocyclopropyl)methoxy)benzoic acid, and in the same manner as in Step A of Example 4 and Step D of Example 83, the title compound was obtained.

출처 및 근거

ORD 기록
ord-523a86e6d94042bb8dc638331938765d
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133129B2

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