HCID 178461781, 화합물 → HCID 178461779, 화합물
반응식
[OH:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][N:5]=[C:4]([O:11][CH2:12][C@@H:13]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH3:14])[CH:3]=1>[Pd].CO>[NH2:8][C:7]1[C:2]([OH:1])=[CH:3][C:4]([O:11][CH2:12][C@@H:13]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:20])([CH3:19])[CH3:21])[CH3:14])=[N:5][CH:6]=1참가 물질
4
실험 절차
A mixture of tert-butyl ((2S)-1-((4-hydroxy-5-nitropyridin-2-yl)oxy)propan-2-yl)carbamate (3.84 g) and 10% palladium/carbon (containing water (50%), 0.40 g) and methanol (50 mL) was stirred at room temperature for 15 hr under a hydrogen atmosphere. The catalyst was removed by filtration, and the obtained filtrate was concentrated under reduced pressure to give the title compound (3.35 g).
후처리
- customThe catalyst was removed by filtration
- concentrationthe obtained filtrate was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-2f683fcf1ecb4ddbb1dd37aa048a9dba
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09133129B2
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