((1R)-2,2-difluorocyclopropyl)methyl 4-nitrobenzenesulfonate → ethyl 5-(((1R)-2,2-difluorocyclopropyl)methoxy)-3-fluoropyridine-2-carboxylate

반응식

[F:1][C:2]1[C:3]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[N:4][CH:5]=[C:6]([OH:8])[CH:7]=1.[N+](C1C=CC(S(O[CH2:27][C@H:28]2[CH2:30][C:29]2([F:32])[F:31])(=O)=O)=CC=1)([O-])=O>>[F:31][C:29]1([F:32])[CH2:30][C@@H:28]1[CH2:27][O:8][C:6]1[CH:7]=[C:2]([F:1])[C:3]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[N:4][CH:5]=1

참가 물질

반응물 2

HCID 86731320((1R)-2,2-difluorocyclopropyl)methyl 4-nitrobenzenesulfonate

HCID 86731382Ethyl 3-fluoro-5-hydroxypicolinate

생성물 1

HCID 86731383ethyl 5-(((1R)-2,2-difluorocyclopropyl)methoxy)-3-fluoropyridine-2-carboxylate

실험 절차

Using ethyl 3-fluoro-5-hydroxypyridine-2-carboxylate and ((1R)-2,2-difluorocyclopropyl)methyl 4-nitrobenzenesulfonate, and in the same manner as in Example 5, the title compound was obtained.

출처 및 근거

ORD 기록: ord-1e327da9fda844d3b601a50adca45c0f
출처 데이터셋: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09133129B2

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