2-Chloro-5-(cyclopropylmethoxy)pyrimidine → HCID 86731416, 화합물

반응식

Cl[C:2]1[N:7]=[CH:6][C:5]([O:8][CH2:9][CH:10]2[CH2:12][CH2:11]2)=[CH:4][N:3]=1.[O:13]1[C:21]2[CH:20]=[C:19]([O:22][CH2:23][C@@H:24]([NH:26][C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30])[CH3:25])[N:18]=[CH:17][C:16]=2[N:15]=[CH:14]1>>[CH:10]1([CH2:9][O:8][C:5]2[CH:4]=[N:3][C:2]([C:14]3[O:13][C:21]4[CH:20]=[C:19]([O:22][CH2:23][C@@H:24]([NH:26][C:27](=[O:33])[O:28][C:29]([CH3:31])([CH3:30])[CH3:32])[CH3:25])[N:18]=[CH:17][C:16]=4[N:15]=3)=[N:7][CH:6]=2)[CH2:12][CH2:11]1

참가 물질

반응물 2

HCID 534406182-Chloro-5-(cyclopropylmethoxy)pyrimidine

HCID 86731417HCID 86731417, 화합물

생성물 1

HCID 86731416HCID 86731416, 화합물

실험 절차

Using 2-chloro-5-(cyclopropylmethoxy)pyrimidine and tert-butyl ((2S)-1-([1,3]oxazolo[4,5-c]pyridin-6-yloxy)propan-2-yl)carbamate, and in the same manner as in Step B of Example 22, the title compound was obtained.

출처 및 근거

ORD 기록: ord-66a412fb43ba4ed588591285eae06009
출처 데이터셋: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09133129B2

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