3-chloro-5-(((1R)-2,2-difluorocyclopropyl)methoxy)pyridine-2-carboxylic acid → HCID 178461780, 화합물

반응식

[Cl:1][C:2]1[C:3]([C:15]([OH:17])=O)=[N:4][CH:5]=[C:6]([O:8][CH2:9][C@H:10]2[CH2:12][C:11]2([F:14])[F:13])[CH:7]=1.[NH2:18][C:19]1[C:20]([OH:37])=[CH:21][C:22]([O:25][CH2:26][C@@H:27]([NH:29][C:30](=[O:36])[O:31][C:32]([CH3:35])([CH3:34])[CH3:33])[CH3:28])=[N:23][CH:24]=1>>[Cl:1][C:2]1[C:3]([C:15]([NH:18][C:19]2[C:20]([OH:37])=[CH:21][C:22]([O:25][CH2:26][C@@H:27]([NH:29][C:30](=[O:36])[O:31][C:32]([CH3:34])([CH3:33])[CH3:35])[CH3:28])=[N:23][CH:24]=2)=[O:17])=[N:4][CH:5]=[C:6]([O:8][CH2:9][C@H:10]2[CH2:12][C:11]2([F:13])[F:14])[CH:7]=1

참가 물질

반응물 2

HCID 867313973-chloro-5-(((1R)-2,2-difluorocyclopropyl)methoxy)pyridine-2-carboxylic acid

HCID 178461779HCID 178461779, 화합물

생성물 1

HCID 178461780HCID 178461780, 화합물

실험 절차

Using 3-chloro-5-(((1R)-2,2-difluorocyclopropyl)methoxy)pyridine-2-carboxylic acid and tert-butyl ((2S)-1-((5-amino-4-hydroxypyridin-2-yl)oxy)propan-2-yl)carbamate, and in the same manner as in Step E of Example 139, the title compound was obtained.

출처 및 근거

ORD 기록: ord-fcdee00c12ab4e29af94c24791ca075b
출처 데이터셋: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09133129B2

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