Acetic Acid → 5,8-Difluoro-2,3-dihydrophthalazine-1,4-dione

HRID 227754노트

반응식

HRID 227754 반응식
[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]2[C:3]=1[C:4](=O)[O:5][C:6]2=[O:12].C([O-])(=O)C.[Na+].C(O)(=O)C.[NH2:23][NH2:24]>O>[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:7]2[C:3]=1[C:4](=[O:5])[NH:23][NH:24][C:6]2=[O:12]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 9321HydrazineHCID 5139183,6-Difluorophthalic anhydrideHCID 517045Sodium Acetate

생성물 1

HCID 667320095,8-Difluoro-2,3-dihydrophthalazine-1,4-dione

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 4,7-difluoroisobenzofuran-1,3-dione (1.00 g, 5.43 mmol) and sodium acetate (0.535 g, 6.52 mmol) was added water (14 mL), acetic acid (7.15 ml, 125 mmol) and hydrazine (0.205 ml, 6.52 mmol)(slowly). A water condenser was attached and the mixture was heated to reflux for 20 hours. Cooled to RT and filtered the resulting solid. Washed with water and dried to yield 5,8-difluoro-2,3-dihydrophthalazine-1,4-dione as a white solid.

후처리

  1. customA water condenser was attached
  2. temperaturethe mixture was heated
  3. temperatureto reflux for 20 hours
  4. filtrationfiltered the resulting solid
  5. washWashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-5460c3ba3c4a4c8fa56cd25eccb4a0ca
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560551B2

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