Methyl 2-(hydroxymethyl)pyridine-4-carboxylate → Methyl 2-formylisonicotinate
반응식
[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[CH:6]=[CH:5][N:4]=1>C(Cl)Cl.O=[Mn]=O>[CH:2]([C:3]1[CH:8]=[C:7]([C:9]([O:11][CH3:12])=[O:10])[CH:6]=[CH:5][N:4]=1)=[O:1]참가 물질
4
실험 절차
To a solution of methyl 2-(hydroxymethyl)pyridine-4-carboxylate (30 g, 179.64 mmol) in DCM (1 L) was added MnO2 (93.77 g. 1.0778 mol) at r.t. and stirred overnight. The reaction mixture was then filtered and concentrated to afford the title compound (21.3 g, 72%). [M+H] Calc'd for C8H7NO3, 166. Found, 166.
후처리
- filtrationThe reaction mixture was then filtered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-6c865212858146c2b7ba0698c5b715d8
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09133166B2
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