Methanol → 2-(3-Chloro-2-fluorophenyl)ethanamine

HRID 2277578노트

반응식

HRID 2277578 반응식
[Cl:1][C:2]1[C:3]([F:11])=[C:4]([CH2:8][C:9]#[N:10])[CH:5]=[CH:6][CH:7]=1.B.CO>C1COCC1>[Cl:1][C:2]1[C:3]([F:11])=[C:4]([CH2:8][CH2:9][NH2:10])[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 6331BoraneHCID 27737242-(3-Chloro-2-fluorophenyl)acetonitrile

생성물 1

HCID 534035832-(3-Chloro-2-fluorophenyl)ethanamine수율 90%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of (3-chloro-2-fluoro-phenyl)-acetonitrile (1.48 g, 8.8 mmol) in anhydrous THF (20 mL) was added a solution of borane (20 mL, 1M in THF) dropwise. The resulting reaction mixture was heated at reflux temperature for 2 hours. After cooling to room temperature, MeOH was added and the mixture was stirred at room temperature for additional 30 min. After removal of volatiles under reduced pressure, desired title product (1.30 g, 90%) was obtained as oil. MS: 174.0 (M+H)+.

후처리

  1. customThe resulting reaction mixture
  2. temperaturewas heated
  3. temperatureat reflux temperature for 2 hours
  4. customAfter removal of volatiles under reduced pressure

출처 및 근거

ORD 기록
ord-c55e2cb4209f4c8fbe6ae01e86124df8
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133158B2

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