HCID 86685931, 화합물 → HCID 71743949, 화합물

HRID 2277603노트

반응식

HRID 2277603 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6](CC1C=CC(OC)=CC=1)[C:5]2([CH3:22])[CH3:21]>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[NH:6][C:5]2([CH3:22])[CH3:21]

참가 물질

3

반응물 1

HCID 86685931HCID 86685931, 화합물

생성물 1

HCID 71743949HCID 71743949, 화합물수율 85.2%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

A solution of 5-chloro-2-(4-methoxy-benzyl)-3,3-dimethyl-2,3-dihydro-isoindol-1-one (0.38 g, 1.2 mmol) in trifluoro acetic acid (5 mL) was heated to reflux for 20 hours. After removal of trifluoro acetic acid under reduced pressure, the crude product was purified by flash column chromatography (silica gel 14 g, 5% to 50% ethyl acetate in DCM) to give the title compound (0.20 g, 85%) as a white solid. MS: 196.1 (M+H+).

후처리

  1. temperatureto reflux for 20 hours
  2. customAfter removal of trifluoro acetic acid under reduced pressure
  3. customthe crude product was purified by flash column chromatography (silica gel 14 g, 5% to 50% ethyl acetate in DCM)

출처 및 근거

ORD 기록
ord-2419ad2b92e6414dad2c21b4e5ecc319
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133158B2

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