Water → 2-chloro-7,7-dimethyl-5H,6H,7H-pyrrolo[3,4-b]pyridin-5-one

반응식

[Cl:1][C:2]1[N:7]=[C:6]2[C:8]([CH3:22])([CH3:21])[N:9](CC3C=CC(OC)=CC=3)[C:10](=[O:11])[C:5]2=[CH:4][CH:3]=1.O.CCOC(C)=O>CC#N>[Cl:1][C:2]1[N:7]=[C:6]2[C:8]([CH3:22])([CH3:21])[NH:9][C:10](=[O:11])[C:5]2=[CH:4][CH:3]=1

참가 물질

실험 절차

To solution of 2-chloro-6-(4-methoxy-benzyl)-7,7-dimethyl-6,7-dihydro-pyrrolo[3,4-b]pyridin-5-one (1.58 g, 5.0 mmol) in CH3CN (20 mL) was added ceric ammonium nitrate (8.2 g, 15.0 mmol) at room temperature. The reaction mixture was stirred at room temperature for 3 hours before water and EtOAc was added into the mixture. The organic layer was separated, dried over anhy. Na2SO4, filtered and concentrated in vacuo to give a crude product which was then purified by silica gel column chromatography to give title compound (617 mg, 63%) as a solid. MS: 197.2 (M+H+).