4-Methoxybenzylamine → HCID 89600014, 화합물

HRID 2277625노트

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HRID 2277625 반응식
CO[C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:5]=1[CH2:11]Br.[CH2:14]([NH2:23])[C:15]1[CH:22]=[CH:21][C:18]([O:19][CH3:20])=[CH:17][CH:16]=1>C1COCC1>[F:10][C:7]1[CH:6]=[C:5]2[C:4](=[CH:9][CH:8]=1)[C:3](=[O:13])[N:23]([CH2:14][C:15]1[CH:22]=[CH:21][C:18]([O:19][CH3:20])=[CH:17][CH:16]=1)[CH2:11]2

참가 물질

4

반응물 2

HCID 754524-MethoxybenzylamineHCID 18323864Methyl 2-(bromomethyl)-4-fluorobenzoate

생성물 1

HCID 89600014HCID 89600014, 화합물수율 69.7%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of 2-bromomethyl-4-fluoro-benzoic acid methyl ester (17 g, 68.8 mmol) in THF (200 mL) was added PMBNH2 (23.6 g, 172 mmol) at 0° C. After stirring at room temperature for 16 hours, the reaction mixture was concentrated in vacuo to give a crude product which was then purified by column chromatography to give the title compound (13 g, yield 69%) as a solid.

후처리

  1. concentrationthe reaction mixture was concentrated in vacuo
  2. customto give a crude product which
  3. customwas then purified by column chromatography

출처 및 근거

ORD 기록
ord-d8426ee9f4b04d828ee845957fe5d845
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133158B2

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