HCID 71743949, 화합물 → HCID 86686010, 화합물

HRID 2277717노트

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HRID 2277717 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[NH:6][C:5]2([CH3:13])[CH3:12].Br[C:15]1[CH:16]=[N:17][CH:18]=[C:19]([N:21]2[CH2:25][CH2:24][C@H:23]([O:26][Si](C(C)(C)C)(C)C)[CH2:22]2)[CH:20]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C:15]1[CH:16]=[N:17][CH:18]=[C:19]([N:21]3[CH2:25][CH2:24][C@H:23]([OH:26])[CH2:22]3)[CH:20]=1)[C:5]2([CH3:13])[CH3:12]

참가 물질

3

반응물 2

HCID 71743949HCID 71743949, 화합물HCID 86686011Pyridine, 3-bromo-5-[(3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-pyrrolidinyl]-

생성물 1

HCID 86686010HCID 86686010, 화합물

실험 절차

In analogy to the procedure described for the preparation of example 137, 5-chloro-3,3-dimethyl-2,3-dihydro-isoindol-1-one (intermediate A-12), 3-bromo-5-[(S)-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-1-yl]-pyridine was used (step C) to yield the title compound as a white solid. MS: 358.1 (M+H+).

출처 및 근거

ORD 기록
ord-f198f908841d4299bebb6de9e28c239f
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133158B2

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