Trifluoroacetic acid → HCID 89677464, 화합물

HRID 2278202노트

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HRID 2278202 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)[C:3]=1[CH2:13][N:14]1[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N:8]2[CH2:9][CH2:10][CH2:11][CH2:12]2)[C:3]=1[CH2:13][N:14]1[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 89676972HCID 89676972, 화합물

생성물 1

HCID 89677464HCID 89677464, 화합물수율 132.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
0 °C

실험 절차

A 100 mL round-bottom flask was charged with tert-butyl 4-[[2-chloro-6-(pyrrolidin-1-yl)phenyl]methyl]piperazine-1-carboxylate (500 mg, 1.32 mmol, 1.00 equiv), dichloromethane (10 mL). The mixture was cooled to 0° C. Trifluoroacetic acid (1 mL) was added dropwise at 0° C. The resulting solution was stirred overnight at room temperature and concentrated under reduced pressure to yield 490 mg (crude) of 1-[[2-chloro-6-(pyrrolidin-1-yl)phenyl]methyl]piperazine as yellow oil. LCMS (ESI, m/z): 280 [M+H]+.

후처리

  1. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-354d36e6526249c8be4d6c1ceb1d5d88
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133148B2

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