Trifluoroacetic acid → HCID 89676991, 화합물

HRID 2278254노트

반응식

HRID 2278254 반응식
[CH3:1][C:2]1[C:7]([CH2:8][N:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[CH:6][CH:5]=[C:4]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[CH3:28])[N:3]=1.FC(F)(F)C(O)=O>ClCCl>[CH3:1][C:2]1[C:7]([CH2:8][N:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)=[CH:6][CH:5]=[C:4]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[CH3:28])[N:3]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 89677097HCID 89677097, 화합물

생성물 1

HCID 89676991HCID 89676991, 화합물수율 87.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A 100 mL round-bottom flask was charged with tert-butyl 4-[[2-methyl-6-(2-methylphenyl)pyridin-3-yl]methyl]piperazine-1-carboxylate (800 mg, 2.40 mmol, 1.00 equiv), dichloromethane (20 mL), trifluoroacetic acid (4 mL) was added dropwise. The resulting solution was stirred overnight at room temperature. The resulting mixture was concentrated under reduced pressure to provide 590 mg (crude) of 1-[[2-methyl-6-(2-methylphenyl)pyridin-3-yl]methyl]piperazine as yellow oil. LCMS (ESI, m/z): 282 [M+H]+.

후처리

  1. additionwas added dropwise
  2. concentrationThe resulting mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3621a89bc93841eab2084f5dcb3a0e4e
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133148B2

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