Trifluoroacetic acid → Piperazine, 1-[[5-(3-fluorophenyl)-2-pyridinyl]methyl]-

HRID 2278271노트

반응식

HRID 2278271 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][N:15]3[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1.FC(F)(F)C(O)=O>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[N:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 89677105HCID 89677105, 화합물

생성물 1

HCID 89676965Piperazine, 1-[[5-(3-fluorophenyl)-2-pyridinyl]methyl]-수율 72%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A 100 mL round-bottom flask, was charged with tert-butyl 4-[[5-(3-fluorophenyl)pyridin-2-yl]methyl]piperazine-1-carboxylate (950 mg, 2.56 mmol, 1.00 equiv), dichloromethane (15 mL), trifluoroacetic acid (2 mL). The resulting solution was stirred for overnight at room temperature. The resulting mixture was concentrated under reduced pressure to provide 500 mg (crude) of 1-[[5-(3-fluorophenyl)pyridin-2-yl]methyl]piperazine as yellow oil. LCMS (ESI, m/z): 272 [M+H]+.

후처리

  1. concentrationThe resulting mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-1d95816ae3ec4a22abb7fdca3ecbfdbe
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133148B2

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