Water → HCID 57388438, 화합물

HRID 2278677노트

반응식

HRID 2278677 반응식
[CH3:1][O:2][C:3](=[O:15])[CH2:4][C:5]1[N:10]=[C:9](Cl)[C:8]([F:12])=[C:7]([O:13][CH3:14])[N:6]=1.O.C(OCC)(=O)C.[NH:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1>>[CH3:1][O:2][C:3](=[O:15])[CH2:4][C:5]1[N:6]=[C:7]([O:13][CH3:14])[C:8]([F:12])=[C:9]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[N:10]=1

참가 물질

5

반응물 4

HCID 962WaterHCID 8083MorpholineHCID 8857Ethyl AcetateHCID 86699294(4-Chloro-5-fluoro-6-methoxypyrimidin-2-yl)acetic acid methyl ester

생성물 1

HCID 57388438HCID 57388438, 화합물

실험 절차

A solution of 8.36 g of (4-chloro-5-fluoro-6-methoxypyrimidin-2-yl)acetic acid methyl ester in 76 ml of morpholine is stirred at ambient temperature for one and a half hours. The reaction medium is concentrated under reduced pressure. The residue obtained is taken up with 50 ml of water and 200 ml of ethyl acetate. After settling out, the organic phase is dried over magnesium sulfate, filtered, and then concentrated under reduced pressure, so as to give 8.86 g of (5-fluoro-4-methoxy-6-morpholin-4-ylpyrimidin-2-yl)acetic acid methyl ester in the form of a beige solid, the characteristics of which are the following:

후처리

  1. concentrationThe reaction medium is concentrated under reduced pressure
  2. customThe residue obtained
  3. dry with materialthe organic phase is dried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-9cb1bcf39d2d43e1880b3ccf411981b6
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133168B2

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