Ambroxol → (1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetic acid--4-(((2-amino-3,5-dibromophenyl)methyl)amino)cyclohexan-1-ol (1/1)

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The mixture of ambroxol base (20.0 g, 0.052 moles) and carbon tetrachloride (100 ml) was heated at 45-50° C. for 1-2 minutes to prepare a clear solution. Carbon tetrachloride (100 ml) and theophylline-7-acetic acid (12.6 g, 0.052 moles) were charged in a round bottom flask and heated at 60 to 65° C. To this flask, the prepared solution of ambroxol base in carbon tetrachloride was added under stirring while maintaining the temperature between 60-65° C. during 2-3 minutes. The resulting reaction mixture was stirred at 70-75° C. for 30-35 minutes. The reaction mixture was allowed to cool to room temperature. The separated solid product was filtered and washed with carbon tetrachloride and dried. The yield of Acebrophylline obtained was 95.2%.

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