Ethanol → HCID 178440334, 화합물

HRID 2278860노트

반응식

HRID 2278860 반응식
O=[C:2]([CH2:7][CH2:8][CH3:9])[C:3]([O:5]C)=O.[F:10][C:11]1[CH:30]=[CH:29][CH:28]=[CH:27][C:12]=1[CH2:13][N:14]1[C:18]2=[N:19][CH:20]=N[CH:22]=[C:17]2[C:16]([C:23](=[NH:26])[NH:24][NH2:25])=[N:15]1.[CH2:31](O)C>>[F:10][C:11]1[CH:30]=[CH:29][CH:28]=[CH:27][C:12]=1[CH2:13][N:14]1[C:18]2=[N:19][CH:20]=[CH:31][CH:22]=[C:17]2[C:16]([C:23]2[N:24]=[N:25][C:2]([CH2:7][CH2:8][CH3:9])=[C:3]([OH:5])[N:26]=2)=[N:15]1

참가 물질

4

반응물 3

HCID 702Ethanol2회HCID 642256Methyl 2-OxovalerateHCID 178512736HCID 178512736, 화합물

생성물 1

HCID 178440334HCID 178440334, 화합물

실험 절차

0.916 g (7.035 mmol) of methyl 2-oxopentanoate in 15 ml of ethanol were initially introduced and heated to reflux. Then, 2.000 g (7.035 mmol) of 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-d]pyrimidine-3-carboximidohydrazide suspended in 20 ml of ethanol were added and the mixture was heated under reflux overnight. After cooling, the mixture was filtered off with suction, and the filtercake was washed with a little ethanol and dried under high vacuum. This gave 1.75 g of the target compound (purity 92%; 63% of theory).

후처리

  1. temperatureheated to reflux
  2. additionwere added
  3. temperaturethe mixture was heated
  4. temperatureunder reflux overnight
  5. temperatureAfter cooling
  6. filtrationthe mixture was filtered off with suction
  7. washthe filtercake was washed with a little ethanol
  8. customdried under high vacuum

출처 및 근거

ORD 기록
ord-00eec5bf659c4cf48ab0c61a2325d3a0
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133191B2

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