2-Chloroethyl isocyanate → HCID 90426517, 화합물

HRID 2278944노트

반응식

HRID 2278944 반응식
[CH3:1][O:2][C:3]1([CH2:6][CH2:7][NH2:8])[CH2:5][CH2:4]1.[Cl:9][CH2:10][CH2:11][N:12]=[C:13]=[O:14]>C1COCC1>[Cl:9][CH2:10][CH2:11][NH:12][C:13]([NH:8][CH2:7][CH2:6][C:3]1([O:2][CH3:1])[CH2:5][CH2:4]1)=[O:14]

참가 물질

4

반응물 2

HCID 160352-Chloroethyl isocyanateHCID 838721782-(1-Methoxycyclopropyl)ethanamine

생성물 1

HCID 90426517HCID 90426517, 화합물수율 81%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A 0° C. solution of 2-(1-methoxycyclopropyl)ethanamine (0.361 g, 2.413 mmol) in THF (15 mL) was treated drop-wise with 2-chloroethyl isocyanate (0.226 mL, 2.65 mmol), allowed to warm to RT, stirred overnight, then concentrated to dryness. The residue was treated with toluene and concentrated to dryness (twice) to afford 1-(2-chloroethyl)-3-(2-(1-methoxycyclopropyl)ethyl)urea (429 mg, 81%) as a yellow oil. MS (ESI) m/z: 221.1 (M+H+).

후처리

  1. concentrationconcentrated to dryness
  2. additionThe residue was treated with toluene
  3. concentrationconcentrated to dryness (twice)

출처 및 근거

ORD 기록
ord-4aaa752e2e6643b8b0c943b725977f25
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133183B2

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