2-Tetrahydropyranyl 4-benzyloxycarbonylaminobicyclo[2,2,2]octane-1-carboxylate → 2-Tetrahydropyranyl 4-aminobicyclo[2,2,2]octane-1-carboxylate

HRID 227932노트

반응식

HRID 227932 반응식
C(OC([NH:11][C:12]12[CH2:19][CH2:18][C:15]([C:20]([O:22][CH:23]3[CH2:28][CH2:27][CH2:26][CH2:25][O:24]3)=[O:21])([CH2:16][CH2:17]1)[CH2:14][CH2:13]2)=O)C1C=CC=CC=1.[H][H]>C(O)C.[C].[Pd]>[NH2:11][C:12]12[CH2:17][CH2:16][C:15]([C:20]([O:22][CH:23]3[CH2:28][CH2:27][CH2:26][CH2:25][O:24]3)=[O:21])([CH2:18][CH2:19]1)[CH2:14][CH2:13]2

참가 물질

5

반응물 2

HCID 231496802-Tetrahydropyranyl 4-benzyloxycarbonylaminobicyclo[2,2,2]octane-1-carboxylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 231496982-Tetrahydropyranyl 4-aminobicyclo[2,2,2]octane-1-carboxylate수율 99.6%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

2-Tetrahydropyranyl 4-benzyloxycarbonylaminobicyclo[2.2.2]octane-1-carboxylate (548 mg) was dissolved in ethanol (6 mL). To this solution, 10% palladium-carbon (60 mg) was added and the mixture was stirred at room temperature for 2 hours in a stream of hydrogen. The catalyst in the reaction mixture was filtered through a Celite pad and the filtered catalyst, together with the Celite pad, washed with ethanol. The filtrate and the washings were combined and concentrated under reduced pressure. The resulting residue was dried under reduced pressure to give 2-tetrahydropyranyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (357 mg).

후처리

  1. filtrationThe catalyst in the reaction mixture was filtered through a Celite pad
  2. washthe filtered catalyst, together with the Celite pad, washed with ethanol
  3. concentrationconcentrated under reduced pressure
  4. customThe resulting residue was dried under reduced pressure

출처 및 근거

ORD 기록
ord-4da56854f69b40ecaf4b601b150c63d6
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560569B2

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