Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile → (2S)-1-[[(4-carbamoylbicyclo[2.2.2]oct-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile | HCID 11031276 | — |
| 반응물 | 4-Aminobicyclo[2.2.2]octane-1-carboxamide | HCID 23150530 | — |
| 생성물 | (2S)-1-[[(4-carbamoylbicyclo[2.2.2]oct-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile | HCID 57756756 | 59.5% |
반응 단계
Using 4-aminobicyclo[2.2.2]octane-1-carboxamide (50.0 mg) and (2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile (56.9 mg), the same procedure was followed as in Example 1 to give (2S)-1-[[(4-carbamoylbicyclo[2.2.2]oct-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile (47.5 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07560569B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-5c1122efecf746319f65723b16a3fa5c |
| 출처 메모 | uspto-grants-2009_07 |