Dichloromethane → HCID 86705536, 화합물

HRID 2279549노트

반응식

HRID 2279549 반응식
[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[CH2:12][C:13]([OH:15])=O.C(Cl)[Cl:17].C(Cl)(=O)C(Cl)=O>CN(C=O)C>[F:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[CH2:12][C:13]([Cl:17])=[O:15]

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 38635672-Fluoro-4-(trifluoromethyl)phenylacetic acid

생성물 1

HCID 86705536HCID 86705536, 화합물수율 96%

시약·촉매·용매 1

HCID 6228Dimethylformamide촉매

실험 절차

To a solution of 2-(2-fluoro-4-(trifluoromethyl)phenyl)acetic acid (5 g, 22.509 mmol, CASRN 209991-64-0) in DCM (112 mL, 22.509 mmol) was added oxalyl chloride (2.94 mL, 33.8 mmol) and 3 drops of DMF. The solution was stirred at RT overnight and concentrated to dryness to afford 5.2 g (88.2%) of 2-(2-fluoro-4-(trifluoromethyl)phenyl)acetyl chloride.

후처리

  1. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-2a967aaefce7479188a9b0c9705f9fc1
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133187B2

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