Ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate → HCID 59579876, 화합물

HRID 2279647노트

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HRID 2279647 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[C:7](=[S:9])[NH2:8].[CH2:10]([O:12][C:13](=[O:22])[CH:14](Cl)[C:15](=O)[C:16]([F:19])([F:18])[F:17])[CH3:11]>CN(C=O)C>[CH2:10]([O:12][C:13]([C:14]1[S:9][C:7]([C:2]2[N:3]=[CH:4][CH:5]=[CH:6][N:1]=2)=[N:8][C:15]=1[C:16]([F:17])([F:18])[F:19])=[O:22])[CH3:11]

참가 물질

4

반응물 2

HCID 2737165Ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoateHCID 23273397Pyrimidine-2-carbothioamide

생성물 1

HCID 59579876HCID 59579876, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
110 °C

실험 절차

A mixture of 2-pyrimidinecarbothioamide (2 g) and 2-chloro-4,4,4-trifluoro-3-oxo-butyric acid ethyl ester (3.2 g) in 10 mL of DMF is heated at 110° C. with stirring overnight. The mixture is concentrated under vacuum, and purified on silica gel column to afford the title compound.

후처리

  1. concentrationThe mixture is concentrated under vacuum
  2. custompurified on silica gel column

출처 및 근거

ORD 기록
ord-fff039fd3a8c4c6a8280c0674ddc2abd
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133204B2

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