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Ethyl Acetate → HCID 68768652, 화합물

HRID 2279653
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HRID 2279653 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[C:7]1[S:8][C:9]([C:16]([OH:18])=O)=[C:10]([C:12]([F:15])([F:14])[F:13])[N:11]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]([N:29]2[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[CH2:27][NH2:28])=[CH:22][CH:21]=1.F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1.CCOC(C)=O>C(#N)C.O>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]([N:29]2[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]2)[CH2:27][NH:28][C:16]([C:9]2[S:8][C:7]([C:2]3[N:1]=[CH:6][CH:5]=[CH:4][N:3]=3)=[N:11][C:10]=2[C:12]([F:13])([F:14])[F:15])=[O:18])=[CH:22][CH:21]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 8857Ethyl AcetateHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 166424352-(4-Chlorophenyl)-2-(piperidin-1-yl)ethan-1-amineHCID 59580006HCID 59580006, 화합물

생성물 1

HCID 68768652HCID 68768652, 화합물

시약·촉매·용매 2

HCID 962
Water
용매
HCID 6342Acetonitrile용매

실험 절차

A mixture of 2-pyrimidin-2-yl-4-trifluoromethyl-thiazole-5-carboxylic acid (60 mg), 2-(4-chloro-phenyl)-2-piperidin-1-yl-ethylamine (60 mg), BOP (100 mg) and TEA (40 mg) in ACN (1 mL) is stirred at RT overnight. EtOAc and water added to the mixture and the organic layer is separated, washed twice with water and concentrated in vacuo. The residue is purified by PTLC (10% MeOH in methylene chloride) to give the title compound. MS (M+1)=496.09; RT=1.14 min. *IC50.

후처리

  1. customthe organic layer is separated
  2. washwashed twice with water
  3. concentrationconcentrated in vacuo
  4. customThe residue is purified by PTLC (10% MeOH in methylene chloride)

출처 및 근거

ORD 기록
ord-86ef3cdced1e47be85d00bb3b1f4b22c
출처 데이터셋
uspto-grants-2015_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09133204B2

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