Bromotrimethylsilane → HCID 178485583, 화합물

HRID 2279815노트

반응식

HRID 2279815 반응식
[OH:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:9]=[C:8]([C:10]2[N:15]=[C:14]([C:16](=[O:19])[NH:17][CH3:18])[C:13]([NH:20][C:21]3[C:26]([C:27]([F:30])([F:29])[F:28])=[CH:25][N:24]=[C:23]([NH:31][C:32]4[CH:46]=[CH:45][C:35]([CH2:36][CH2:37][CH2:38][CH2:39][PH:40](=[O:44])[O:41]CC)=[CH:34][C:33]=4[O:47][CH3:48])[N:22]=3)=[CH:12][CH:11]=2)[CH:7]=[N:6]1.Br[Si](C)(C)C>N1C=CC=CC=1>[OH:1][CH2:2][CH2:3][CH2:4][N:5]1[CH:9]=[C:8]([C:10]2[N:15]=[C:14]([C:16](=[O:19])[NH:17][CH3:18])[C:13]([NH:20][C:21]3[C:26]([C:27]([F:29])([F:30])[F:28])=[CH:25][N:24]=[C:23]([NH:31][C:32]4[CH:46]=[CH:45][C:35]([CH2:36][CH2:37][CH2:38][CH2:39][PH:40](=[O:41])[OH:44])=[CH:34][C:33]=4[O:47][CH3:48])[N:22]=3)=[CH:12][CH:11]=2)[CH:7]=[N:6]1

참가 물질

4

반응물 2

HCID 76113BromotrimethylsilaneHCID 178476808HCID 178476808, 화합물2회

생성물 1

HCID 178485583HCID 178485583, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of ethyl (4-{[4-({6-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-(methylcarbamoyl)pyridin-3-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)propylphosphinate (Compound 37B, 10 mg, 0.015 mmol) in pyridine (1 mL) was charged with bromotrimethylsilane (0.012 mL, 0.087 mmol). The reaction was stirred at rt for 20 min. The material was not isolated. MS (ESI): m/z 663.23 [M+H]+. UPLC: tR=0.85 min (polar—2 min).

후처리

  1. customThe material was not isolated
  2. customtR=0.85 min (polar—2 min)

출처 및 근거

ORD 기록
ord-1564163956224e7d88eaccf279d71af0
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133224B2

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