Ethyl hydrogen (4-{[4-({2-(diethylcarbamoyl)-4-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]phenyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate → ethyl hydrogen (4-{[4-({6-[5-cyano-1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-(methylcarbamoyl)pyridin-3-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate

반응식

C(N(CC)C(C1C=C(C2C=NN(CCCO)C=2)C=CC=1NC1C(C(F)(F)F)=CN=C(NC2C=CC(CP(=O)(O)OCC)=CC=2OC)N=1)=O)C.[C:50]([C:52]1[N:56]([CH2:57][CH2:58][CH2:59][OH:60])[N:55]=[CH:54][C:53]=1[C:61]1[N:66]=[C:65]([C:67](=[O:70])[NH:68][CH3:69])[C:64]([NH:71][C:72]2[C:77]([C:78]([F:81])([F:80])[F:79])=[CH:76][N:75]=[C:74]([NH:82][C:83]3[CH:97]=[CH:96][C:86]([CH2:87][P:88](=[O:95])([O:92]CC)[O:89][CH2:90][CH3:91])=[CH:85][C:84]=3[O:98][CH3:99])[N:73]=2)=[CH:63][CH:62]=1)#[N:51]>>[C:50]([C:52]1[N:56]([CH2:57][CH2:58][CH2:59][OH:60])[N:55]=[CH:54][C:53]=1[C:61]1[N:66]=[C:65]([C:67](=[O:70])[NH:68][CH3:69])[C:64]([NH:71][C:72]2[C:77]([C:78]([F:79])([F:81])[F:80])=[CH:76][N:75]=[C:74]([NH:82][C:83]3[CH:97]=[CH:96][C:86]([CH2:87][P:88](=[O:92])([OH:95])[O:89][CH2:90][CH3:91])=[CH:85][C:84]=3[O:98][CH3:99])[N:73]=2)=[CH:63][CH:62]=1)#[N:51]